OTC Pain Meds Effect Gains?

A few weeks back there was a post and someone mentioned that OTC pain relievers can have a negative effect on gains. Can anyone elaborate on this further. Are some worse than others? I’m on a daily 81 mg aspirin is that small amount an issue? I apologize for the revisit to a topic but I couldn’t find the original thread or any info online regarding this. Any info would be greatly appreciated.

~~C