T Nation

Osteocalcin Increases Insulin Sensitivity AND Testosterone?


First post! I feel that it's also related to training but is most suitable here.

A New York Times article today ( http://www.nytimes.com/2011/08/23/health/23bone.html) highlights research suggesting that osteocalcin, a protein created by osteoblasts (and levels of which increase along with bone mineral density) binds to receptors on testicular cells and increases testosterone levels. It stands to reason that increased BMD might improve testosterone levels--suggesting yet another feedback loop in weight training. (Lift weight--increase BMD--increase testosterone--lift more weight.)

Earlier research by the same lab showed that increased osteocalcin also improved insulin sensitivity (and was previously discussed on the boards in this post: http://tnation.T-Nation.com/free_online_forum/diet_performance_nutrition_supplements/osteocalcin_new_research_area ). This would result in additional benefits for physique transformation. Given that insulin and testosterone are fairly well-regarded around here, I thought this might provoke some interest.