When you are training only twice a week ... which is honestly something that I never did myself and never really had clients do (so take my advice with a grain of salt), I believe that you will need more volume per session. Even if you were to produce more cortisol you have 5 days to regulate it down.
It would be a whole body routine because I believe that for maximal growth you need to hit each muscle at least twice per week.
Probably something like:
- 3 big compound movements (one push, one pull, one lower body)
- one pushing muscles superset
- one pulling muscles superset
- one lower body super set
The big compound movements can be trained fairly heavy with 4-5 sets of 4-6 reps or for slightly higher reps, 3-4 sets of 6-8 depending on your goal and neuro type
The supersets would use low stress exercises (machines or isolation work) for 3-4 work sets
Both sessions can either use the same exercises (if your are a "Type 3"), the same big lifts but different supersets (if you are Type 2b) and different exercises completely if you are a Type 2a
I don't mention type 1a and 1b because twice a week training will not work well for them. Well, it is not optimal for anybody but the Type 2 and 3 can still progress fine on it.