T Nation

NSAIDs and Lifting?

Does anyone know whether NSAIDs blunt the response to resistance exercise?

NSAIDs have been shown to inhibit muscle protein synthesis (MPS):

This is probably mediated by suppression of cyclooxygenase-1 (COX-1) activity:

(Acetaminophen inhibits COX-3, which is a subtype of COX-1)

http://www.rndsystems.com/cb_detail_objectname_SP03_COX3.aspx