IME, pinning ED is the best for NPP, but there are some people that get away with 3x/wk or even E3D. But for me, pinning frequency in general needs to be high to mitigate as many sides as possible.
Maybe I am more susceptible to sides, maybe I am more in tune with sides, I’m not really sure. But I do know that I do not deal with many of the sides most people speak of, outside of mood issues.
Most of the NPP I have seen is 100 mg/mL. If that is the concentration you have, then maybe pin 55-60 mL/day, at an EOD frequency, which will put you between 192.5 to 210 mg/wk. I use slin pins with 1/100 mL increments. So at that concentration, I can measure in 1 mg increments.