T Nation

Nolvadex "Cycle" for Gynecomastia

Anyone have success with nolvadex for pre-existing gyno? Found a cited study that found a six to twelve week cycle of twenty milligram of nolvadex was effective in cases with lumps, not just fat tissue.

“Oral tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type.”


Wow that is an awesome study. Thanks for posting the link. An done all the way back in 2004.

I had gyno surgery about 15 yrs ago but it came back although not near as bad. (Came back before trt)

I read the same study plus several others that are similar. I’ve been on tamoxifen for 6-7 weeks. I did 3 weeks at 20mg and then about a month at 40mg that I’m currently at. I’m planning on 40mg for 3 months. So far I have noticed that the glandular growth has gotten softer (not as hard). Granted my gyno really isn’t that visible and mainly on the right side. I can tell a small difference so far. One thing I’ve noticed from many of the studies is that it takes about 3 months to get the best results.

I’ve noticed the tamoxifen (although I can’t be 100% sure it’s the culprit) does seem to cause mild fatigue at 40mg vs 20mg. At 20mg I didn’t notice anything but at 40mg I do. That said, to treat current gyno 40mg is shown to have more of an impact so I’m sticking with it. Judging by your profile pic we have similar body types.

Thanks for you’re response, I’ve just started at 20mgs and am planning to run for 8 weeks. May give 40mgs a shot down the road though

I’ll offer my 2 cents here. I also had pubertal gyno that was made worse in my 20’s with cycling anabolics. I had it removed 8 years ago and when I started TRT 3 years ago it started to come back on one side, very small lumps, but I could feel them. Started 20mg Nolva and in 4 days the lumps were gone. However, I continued taking the Nolva and after a week began experiencing what I think were symptoms of Nolva Toxicity, so I stopped taking it. My theory now is that a 4-5 day course may clear up small gyno flare ups and will not take the drug continually anymore.

I believe tamoxifen has a 7 day half-life so you would probably get the most from it doing more than 5 days. All the studies that were done over a 4 week period concluded that a longer duration would prove better results with 6 months being optimal results. Most seem to get the best results running for at least 3 months. It may come down to the size of the growth with larger taking longer to reverse. Five days seems like too short of a period to have an effect but I don’t know that for a fact. Regardless, if it worked for you then mission accomplished so congrats.

Yeah I kept finding different info regarding the half life, also the suggested dosing. Some studies found benefit using 5mg daily or 10mg EOD. This was also my first time using real Nolva, not from UGL. It has been 2 weeks and I haven’t seen a recurrence of the gyno, but I’m sure it’s possible.