Anthony Roberts: http://www.acmhck.org/index.asp?nid=225
An effective dose of Letrozole (Femara) is .25-.5mg/day (I use .25mgs/day), but be forewarned, if you go over that amount, it can kill your sex drive. Also worth noting is that there?s a rebound effect on your estrogen when you come off Letrozol. Maximum inhibition of the aromatase enzyme has been found to happen at doses as low as 100mcg! (2)
In addition, I?ve used Letro to get rid of my own gyno, as has a friend of mine, and we both used it at a dose of 2.5mgs/day, tapering down to .25mgs/day, and then finally off..the gyno never returned in both our cases.
Letroxole is a AI like anastrozole. It is interesting that AR state that Letrozole has an E rebound effect as does an SERM. The AI lowers E during used and the SERM increases E during use, but they both rebound.... ??
I would use both short term. Do the letro and Nolva, then taper off the Nolva as symptoms reduce and then do letro for a while and taper that. You could do an extended period of anastrozole after that, 1mg/wk. Watch for a loss of libido, that means your E is too low and probably then also bad for your CV system. Maybe some others can come up more specifics. Either one might be enough to do the job. But as AR suggests, it can take a while for letro to build in serum to effective levels.
For any gear that you do in the future, Nolva and arimidex would seem to be non optional. I am inclined for some reason, to want to avoid over use of letro because of the low E effects on cholesterol and endothelial function.