But serms bind to and competitively inhibit the action of E2 at a receptor level via competitive inhibition. E2 rises proportionately with T (regarding tamox, with clomid… zuclomiphene… the rise can be disproportionate). Even with the increase, the action of said increased E2 is minimal as the SERM binds to the ER. Perhaps AFTER PCT if E has disproportionately risen with clomid too much E in ratio with T could induce or exacerbate a the existing negative feedback loop you’re trying too eliminated (priorly induced via gear usage)
AI usage is one of the things we will disagree with. I don’t think it’s required for the vast majority unless dosages are high. If you could explain to me WHY you aromatise too much, provide bloods as proof I’d understand… otherwise I don’t understand the notion of “E2 must be within this range”… with this rhetoric why not crush DHT alongside T? AAS alter the RAAS to induce a pro hypertensive effect. Both aldosterone and estrogen can have an impact on total body fluid balance, but when you’ve got high E2, high DHT etc I don’t always correlate excess water retention with “high E2”… Whenever someone has a bad emotion, “spills over” a bit etc, it’s always “lets eat a bunch of exemestane”… the majority of guys can probably handle 600mg test weekly without an AI. I’ve used 250mg test +20mg dbol for two weeks, no AI… no symptoms… There’s a decent change aldosterone dysregulation could induce fluid retention no? It doesn’t HAVE to be estrogen mediated. Otherwise why does nandrolone tend to induce water retention despite aromatising at roughly 20% to that of test… What about anadrol?
I don’t understand why so many guys on TRT are using AI’s, either. Testosterone REPLACEMENT shouldn’t require an AI… Unless you’ve got klinefelters syndrome, aromatase excess syndrome etc… I don’t understand why you’d need an AI
What’s the oral bioavailability of anadrol. I’ve never been comfortable trying it given the sheer dosages people take to acquire results (50-150mg weekly) this would equate to taking 500-1500mg long esteemed test/deca or whatever pertaining to the amount of base hormone (70mg TNE = 100mg test E etc)… I’m not comfortable going above 400mg weekly… ever… don’t want to die from lethal arrhythmia induced by extensive cardiac enlargement. Even 25mg seems too much, the only oral I’d go to say 25mg daily with (for more than 2 weeks) is oxandrolone…