In my long battle with TRT I still have no libido no matter what I do. I’ve tried low and high doses, frequent and infrequent injections, prop, cream, HCG which unfortunately gives me gyno, etc. My labs are always good. Over the years I’ve had my total T anywhere from 500 to 1300+, SHBG is healthy constant at 35, e2 is always at a good ratio, dhea-s levels are good, thyroid function is great, etc. Dht is always upper normal. Prolactin is usually upper end of the range but lowering it doesn’t seem to help when I experimented.
I ran more extensive labs this time around to check adrenal function and:
DHEA s: 311 (Range: 138.5 - 475.2)
Pregnenolone: 31 (Range <151)
Progesterone: <0.1 (Range < 0.5)
What does this mean? From everything I read, I should have some sort of Progesterone level, and not having it would be a sign of adrenal insufficiency. But, my dhea levels are great, so clearly I’m producing enough pregnenolone from the adrenals, but none of it is converting to progesterone.
I’m still in my 30s, issues with erections would be one thing but literally NO sexual drive whatsoever in my years on TRT is not normal and completely ruins my life and relationships. I’d try coming off but my levels weren’t great before and I’ve been on over 7 years.
Calling on anyone with experience in this for help, @highpull or others have you ever seen anything like this being the cause of no libido, and either way, what are the fixes if nothing seems to be working?