I have been working with an endocrinologist and due to my ongoing symptoms which have been present for well over 10 years. We have decided for me to start TRT. Testosterone gel, 30mg per day. I am 28 years old and started yesterday.
For information, my labs are;
FSH 2.08 IU/L (1.5 - 12.4)
LH 4.2 IU/L (1.7 - 8.6)
Oestradiol 54.8 pmol/L (41 - 159)
Testosterone 15.2 nmol/L (8.64 - 29)
Free Test - Calc 0.172 nmol/L (0.2 - 0.62)
DHEA-S 3.440 umol/L (4.34 - 12.2)
Cortisol 443 nmol/L (156 - 507)
TSH 2.63 mlU/L (0.27 - 4.2)
Free T3 3.48 pmol/L (3.1 - 6.8)
Free Thyroxine 18.200 pmol/L (12 - 22)
SHBG 113 nmol/L (18.3 - 54.1)
Albumin 50.9 nmol/L (35 - 50)
Insulin 1.73 mlU/L (2.6 - 24.9)
HbA1c 22.65 mmol/mol (20 - 42)
CRP HS 0.86 mg/L (<5)
IGF-1 25.9 nmol/L (10.9 - 33.7)
Growth Hormone 1.0 ug/L (test suggests normal)
MCV & MCH both always slightly above ref, but only very slightly.
Liver & kidney health good and all within ranges.
Cholesterol and HDL only slightly above ref.
I have also had a DUTCH test which showed Progesterone, Estrogens, Androgens and all Metabolites all at low end of range or below range. A poor sight to see to be honest.
My symptoms are all those associated with low testosterone, suspect it is because of my very high SHBG and low total T.
- No drive
- Loss of muscle mass, difficult to gain muscle
- No libido
- Feel fragile, like an old man
- Thin skin and poor wound healing
- I feel as if I haven’t developed into an adult
I could go on and on.
But I also have oily T-zone and facial acne. I have had acne since I was around 15/16 years old.
I don’t understand why, as my blood markers all seem to suggest my androgens are low, hence no acne.
I’m wondering if anyone has experienced anything like this before? My doctor is convinced that my acne is not related to my hormones and very high SHBG, but I think it could be, though research is not in my favour.
My sleep is also rock bottom. I wake up anywhere from 4-6 times a night to urinate. This started about 18 months ago, at this time of my life I was going through a very stressful period, I moved home and under the guidance of a functional medicine practitioner started supplementing with bio-identical hormones DHEA, Progesterone and Prognenolone - something at that time has triggered the sleep issues and I can’t help but think it was due to supplementing with the above. I stopped within a month of starting due to the sleep issues and sleep hasn’t never been back to normal since.
To top things off I have MTHFR gene.
I have had an pituitary MRI and it looks fine.
I’m wondering if I have genetic preposition which elevates my SHBG and starting TRT may lower it, then raise my Free T and balance my hormones, and potentially stop my acne. Seems backwards but I’m just not sure.
I don’t know if this is the best place for this, but I hope you can let me know your thoughts. Particularly on the acne and sleep issues. The acne is debilitating.
Thanks for your time all.