Been following this forum for years, finally decided to participate and seek your advice. my Pregnenolone is very low, and suspect a lot of issue.
I had labs run couple years ago after suspecting I had high E2, and probably either low T or high aromatase. I spent 9 months with a trainer and couldn't build much muscle, and couldn't cut fat. fast forward to a few years later, I started having really bad memory and focus issues, and really suspected I had low hormones.
Found a DOc who is part of ACAM and is very open to working with me(I have a pharmacology background). We drew labs, I had low T, and low Cortisol about a year ago. Started on T-cyp 1/wk, can't recall dose, I shot it SQ.
He also put me on a different AI, I had never heard of. Letrozole, which is used for lowering E2 with breast cancer, benefit seems to be taken once everywhere two weeks, half life is very long and it's real cheap. I also tried you suggestion for HCG, but with my travel schedule I couldnt keep the stuff cool, so stopped it.
I noticed my mid section lost fat, and overall after a while felt really good. Ended up getting labs and adjusted dosage as I was up at 1200(Quest). But overall felt much better.
I got sick of loading 29g needles and found a compounding pharmacist who said lets try a topical he compounds. He included T, DHEA, and Terrebelus.
I tried it and found I guess I was aromatizing T, and saw my mid section grow, don't think I was absorbing well. So stopped on that after about 8 months, been clean since july. Now looking to address this again. Just pulled latest labs two weeks ago below and other pertinent info below that.
ALBUMIN i 4.3 3.6-5.1 g/dL
GLOBULIN 2.7 1.9-3.7 g/dL (calc)
ALBUMIN/GLOBULIN RATIO . 1.6 1.0-2.5 (calc)
BILIRUBIN, TOTAL . 0.6 0.2-1.2 mg/dL
BILIRUBIN, DIRECT 0.1 < OR = 0.2 mg/dL
BILIRUBIN, INDIRECT 0.5 0.2-1.2 mg/dL (calc)
ALKALINE PHÃ??SPHATASE 70 40-115 U/L
AST 25 10-40 U/L
ALT 25 9-46 U/L
GGT 41 3-95 U/L
TSH 1.73 0.40-4.50 mIU/L
T4, FREE 1.0 0.8-1.8 ng/dL
T3, FREE 2.9 2.3-4.2 pg/mL
T3 REVERSE, LC/MS/MS 22 8-25 ng/dL
TESTOSTERONE, FREE 34.7 46.0-224.0 pg/mL (MD denotes low, obviously)
PREGNENOLONE, LC/MS/MS <5 L 13-208 ng/dL
CBC (INCLUDES DIFF/PLT)
WHITE BLOOD CELL COUNT 6.6 3.8-10.8 Thousand/uL
RED BLOOD CELL COUNT 5.22 4.20-5.80 Million/uL
HEMOGLOBIN 15.0 / 13.2-17.1 g/dL
HEMATOCRIT 45.5 - 38.5-50.0
McV 87.2 80.0-100.0
MCH 28.7 27.0-33.0 pg
MCHC Ã?Â· 33.0 32.0-36.0 g/dL
RDW 13.5 11.0-15.0
PLATELET COUNT 315 140-400 Thousand/uL
MPV 8.7 7.5-11.5
ABSOLUTE NEUTROPHILS 4488 1500-7800 cells/uL
ABSOLUTE LYMPHOCYTES 1558 850-3900 cells/uL
ABSOLUTE MONOCYTES 376 200-950 cells/uL
ABSOLUTE EOSINOPHILS 152 15-500 cells/uL
ABSOLUTE BASOPÃ??ILS 26 0-200 cells/uL
NEUTROPHILS 68.0 %
LYMPHOCYTES 23.6 %
MONOCYTES 5.7 %
EOSINOPHILS 2.3 %
BASOPHILS 0.4 %
DHEA Sulfate 350 0-495 mcg/dL
FSH 3.5 1.6-8.0 mIU/mL
LH 2.1 1.5-9.3 mIU/mL
PROLACTÃ??N 5.3 2.0-18.0 ng/mL
TESTOSTERONE, TOTAL, MALES (ADULT), IA 211 L 250-827 ng/dL (LOW)
ESTRADIOL 37 < or = 39 pq/mL
Vit D,25-OH 42 300-100ng/ml
Cortisol 8AM 0.58 mcg/dL 8-10am 0.04-0.56
Cortisol 12PM 0.09 mcg/dL 8-10am 0.04-0.56
Cortisol 4pM <0.03 mcg/dL 4-6pm < or =0.15
Cortisol 12AM 0.06 mcg/dL 10-11pm < or = 0.09
-describe body and facial hair
Estrogen dominance effects weight around hips, butt, handles, gynecomastia(Since about 14), no facial hair, shave twice a week.
Since starting T therapy, noticed waist go from 38 to 40, which really no change in diet, assume E2 is culprit
-describe where you carry fat and how changed
see above (mid section and chest)
-health conditions, symptoms [history]
Low thyroid, been on desiccated thyroid for years
-Rx and OTC drugs, any hair loss drugs or prostate drugs ever
3grain thyroid compounded, no hair loss or prostate drugs ever
-describe diet [some create substantial damage with starvation diets]
I traditionally dont at in AM, no red meat, lots of vegs, avoid wheat at times, limit dairy.
-describe training [some ruin there hormones by over training]
No energy to work out, do an eliptical occasionally with a HIT program
-testes ache, ever, with a fever?
-how have morning wood and nocturnal erections changed
no morning wood, usually no problem with erections, loss of interest from when younger, but may be stress related with my wife
Considering going back on T-Cyp and the letrozole and poss Hcg per your recommendation.
I like the idea of pre loading 29g syringes, but back loading seems to present opportunity for contamination, found in past I would skip due to lack of time to load. Any new ways to load small guage needle?
Anything you see in the labs besides T and Preg, concern?
I am thinking of maybe starting on preg only and seeing if it increases my T. Any thoughts?
Thanks a bunch..