Sounds very familiar. Nearly identical to the protocol my original hormone doc prescribed. Except that I was doing 180 IU HCH 3X per week. Toward the end, he wanted me to try clomid (similar dose and frequency) as a replacement for HCG. I did it for a while but asked to go back to HCG because I didn’t like how I felt on clomid. We never did follow it up with LH or FSH labs to see if it actually worked.
First, I’d really appreciate it if you could post follow up labs on the new protocol that include LH and FSH. I have yet to see anything published on the subject or even anecdotal case study labs in forums like this. Does clomid help to overcome the negative feedback of TRT? In theory it might, since E2 is the predominate feedback hormone for contorl of gonadotropins, but as I said I have yet to see ANY data supporting the use of clomid while on TRT.
Secondly, regarding the blended T, the dose, and the frequency. I think E3D dosing is optimal for a variety of reasons, so that part is good.
Thirdly, regarding the use of T-prop blended in with T-cyp. It does change the dynamics of dosage calculation and the kinetics of absorption, so it’s difficult to compare mg for mg to T-cyp. T-Prop packs a larger payload of T per mg than T-Cyp because the ester is smaller. T-Prop is 83.7% T while T-cyp is only 68.2% . This makes it difficult to compare to T-cyp on a mg basis. Also, T-prop releases it’s payload about twice as fast of T-cyp, which affects the kinetics of absorption. Here are some calculations from my notes. Basically, you get about 2% more T per mg dose from the blended T than you do from T-cyp and part of it is delivered much faster.
180mg T-Cyp/mL = 180 X .68248 = 122.8464 mg T/mL
20mg T-Prop/mL = 20 X .8372 = 16.744 mg T/mL
TOTAL T = 122.8 + 16.7 = 139.5 mg T/mL
200mg T-Cyp/mL = 200 X .68248 = 136.5 mg T/mL
My experience, you ask? Basically, I see no benefit to the blended T and I’ve migrated to pure T-cyp.
Regarding the total dose of T, given that the blended T is only about 2% more rich in T that T-cyp, I think we can take that part out of the equation and compare the two doses on a mg basis. You are currently injecting 40mg E3D which equates to about 93mg/week. Your prior protocol was 20mg/day = 140mg/week. I can feel the difference between the two protocols.
At 93mg/week, most of my Low t symptoms are abated and my labs are all squarely in the upper end of the normal range. It’s a good starting dose. HOWEVER, I do feel better with a higher dose. I did the following dose-response experiment and monitored my Free T and in the end concluded the (FOR ME), my optimal dose is around 125mg/week in and E3D protocol, and my maximal dose is around 140mg/week. When i go above 140mg, my free T goes into the superphysiological range and I don’t think that’s a good thing to do in the long run. But i do feel better at 140mg than 125mg, I believe this is mostly because it helps me recover better from my workouts, which I conclude is bordering on anabolic steroid use, not TRT.