Whenever I read summaries of studies like this, the first thing I always ask myself is “How do I resemble the study population?”.
Obviously I’m not a rat (well, depends who you ask I guess).
But, the goal of the study seems to be to determine how ‘obese’ people are affected by the excess BCAA + high fat diet.
This is a key paragraph:
“I want to be clear that our animal data suggest that there is nothing wrong with obtaining protein from sources that are high in branched-chain amino acids, as long as you are not eating beyond what your energy needs are,” said Newgard, who is a professor of pharmacology and cancer biology and professor of medicine at Duke. “If you add a lot of unneeded protein to a fatty diet, perhaps that’s where you get into problems. The ancient Greeks were right: everything in moderation.”
One, define ‘obese’.
Two, do the folks who stand to gain the most benefit from BCAA supplementation (eg weightlifters cutting fat under strict diets) fall into that category?
Three, how much carry over is there between a)rats, to b)‘obese people’, to c)semi-athletic (ie somewhat fit) people, to d)elite athletes?
Don’t know. I take BCAA’s around my workouts with a moderately low carb diet (ie high protein/fat) and have seen only beneficial changes, compositionally and verified through bloodwork.