For desensitizing the adrenergic recpetors, would be a good approach in your Neurotyping model use the Bob Rakowski’s protocol of melatonin?
Our gut creates, on the average, more than 100 times the amount of chemistry than our brain has at any moment in time. One of those chemicals is melatonin. It is made at 400 times a higher level in the gut than it is in the brain. Our blood brain barrier is there to separate brain and body chemicals. Melatonin receptors reside in the adrenal cortex and they prevent the pituitary drive of cortisol. As a therapy, Dr. Rakowski has put patients on hourly doses (of 1 mg) of high quality liquid melatonin. The half-life of melatonin is about an hour. It pulls the plug on stress hormones. Seven to 10 days of hourly melatonin can break that central nervous system drive of stress hormones.
In a recent conversation:
But one of the things that I like to talk about is What l call it a stress reset or a Melatonin reset.
One of the things we know that Melatonin does is it actually binds to our stress glands, the adrenal glands, and prevents our central nervous system, our brains’ drive on stress. And maybe we have some technical listeners, but it actually binds to what’s called the adrenal cortical tropin receptor.
Just depending on how much detail we may want to go to in the end when we put the brakes on the stress response and I like to do it for about seven to 10 days with Melatonin every waking hour, we actually reset the body where it can actually start responding to its hormones.
A milligram is sufficient for almost everybody, but they will go up to three in some cases. And quite simply, once they take that Melatonin and it gets into the body, it’s going to actually start immediately buffering the stress response. And there’s a concept in the medical literature over the last decade called Cortisol resistance.
I think a lot of listeners have heard of something called insulin resistance where insulin doesn’t work as well anymore, so the body actually starts making more insulin and there’s some challenges with that because they had increased fat storage and increased inflammatory process, but as the body starts to ignore the effects of the stress Hormone Cortisol, we start losing the benefits of Cortisol, which is a very powerful antiinflammatory, so the body starts making more and more and more cortisol.
As the patient becomes less and less healthy, the body has a harder time clearing that and cortisol has a downside to too much of it. It actually breaks down lean tissue and then it stops or dramatically reduces its ability to control the inflammatory process and literally our brain and body can get more or less stuck in fight or flight with immune suppression, inflammation and just an inability to rest, recover experienced joy, and, and things that we needed on a daily basis to enjoy life and be healthy.