T Nation

Neuropeptide Hunger

stress + high calorie diet = abdominal fat, thanks to neuropeptide Y (NPY). this neurotransmitter is released from sympathetic nerves via stress and when it binds to the NPY2R receptors, it causes a cascade of bunch of things leading to obesity.

so, when this receptor was blocked with a NPY2R antagonist injected into mice abdomen, it showed a 50% decrease in abdominal fat (not BAD). when NPY was injected into mice abdomen, as you’d guess, it showed a 50% increase in abdomens of both lean and already obese mice.

i’d be interested in seeing a NPY2R antagonist mixed with DMSO as a topical cream for abs or even Biotest coming up with their own cream formulation. just an idea.

original journal article in Nature Medicine, intro is here:

www.the-scientist.com/news/home/53357/

floripa

Manipulating levels of that hormone could melt fat from areas where it is not desired and accumulate it where it is needed, the researchers say in the journal Nature Medicine.