Nettle Root suppresses SHBG, so we can expect to raise both Testosterone and Estradiol. I have read that SHBG binds more strongly to Testosterone than to Estradiol, or binds preferentially to Testosterone, so it stands to reason that Stinging Nettle Root would favorably alter the Testosterone: Estradiol ratio.
However, in my own experience, symptomatically, this is not the case. When I take 300mg Nettle Root extract 1-2 times a day, the elevation of testosterone is unmistakable, but the elevation of estradiol is more prominent, even to the point of persistent nipple soreness.
It is it possible that under certain circumstances, Nettle Root's might do more harm than good to T:E levels?
Before anyone asks, I am on TRT. I am not yet on an AI (I'm working on that).