I am 31 years old with low testosterone and i have been trying to get on T replacement therapy since earlier this year but having really bad reactions to all forms of therapy i have tried so far. Initially my doc prescribed me with T. ethanate 150mg/week and HCG 400iu 3x a week. Immediately after taking the first shot of T i started to feel pretty bad. I get dry lips, very jittery and anxious, eczema flareups on face, tightness in chest, irritable. After a a day or two of the shot the symptoms subsided. Then i added in the HCG shots that week and again had the same sort of reaction.
Anyway i persisted for a couple of weeks thinking it would get better but things were getting worse and i started to have high e2 symptoms as well, like nipple sensitivity and increased urination frequency. It was clear that i couldn’t continue so i talked to my doc about it and he asked me to stop the T and continue with HCG only.
So i tried HCG only for a week but even going as low as 100iu still had very bad side effects so i had to stop that as well.
So now the doc thinking that i was allergic to some fillers in the injectables had me try Natesto nasal gel 2x a day. I have only taken a couple doses so far and having the same type of allergic reaction. I would say it is even worse than the injectable.
So i am really perplexed as to what is going on with me. Could it be possible that i am allergic to testosterone itself? I have done a lot of search on the internet to see if anyone else had similar issues but found very little information. Anyway i am not sure what to do next and would really appreciate any advise.
Low T symptoms
Low libido, ED, depression, anxiety, memory problems, lack of muscle mass, fatigue.
Other health issues
eczema, seborrheic dermatitis
I developed really bad food intolerance issues with gluten and dairy around 7 years ago and this was about the same time my low T symptoms started getting bad.
Blood work done prior to any TRT
Thyroid Stimulating Hormone [TSH] 2.62 (0.32-4.00 mIU/L)
Thyroxine Free [Free T4] 15 (9-19 pmol/L)
Triiodothyronine Free [Free T3] 4.1 (3.1-6.2 pmol/L)
Follicle Stimulating Hormone [FSH] 3.3 (1.0-8.0 IU/L)
Luteinizing Hormone [LH] 2.5 (1.0-7.0 IU/L)
Prolactin 7.9 (4.0-19.0 ug/L)
Estradiol <40 (<162 pmol/L)
Dehydroepiandrosterone [DHEA-S] 8.1 (< 15.0 umol/L)
Testosterone 8.9 (8.4 - 28.8 nmol/L)
Testosterone Bioavailable 5.7 (3.6 - 11.2 nmol/L)
Testosterone Free 295 (196-636 pmol/L)
25-Hydroxyvitamin D 157 (75 - 250 nmol/L)
Dihydroxytestosterone 2432 (860 - 3406 pmol/L)