Need Another Reason Not To Get Waisted?

Sure it’s in rats…but it might be true in humans too.

Alcohol Clin Exp Res 2000 Mar;24(3):322-31

Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver.

Lang CH, Frost RA, Kumar V, Wu D, Vary TC.

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033-0850, USA.

BACKGROUND: Acute alcohol intoxication in rats decreases protein synthesis in skeletal muscle and, to a lesser extent, in liver. The purpose of the present study was to examine potential mechanisms for the inhibitory effect of acute ethanol exposure. METHODS: Rats were injected intraperitoneally with either ethanol (75 mmol/kg) or saline, and tissues were examined 2.5 hr later. Rates of protein synthesis in vivo were determined by [3H]phenylalanine incorporation into protein, and various eukaryotic initiation factors (eIFs) were quantitated by Western blot analysis to identify possible mechanisms for regulating translation. RESULTS: Protein synthesis in gastrocnemius and liver was decreased (39% and 21%, respectively) after alcohol administration, compared with saline-injected control animals. Alcohol administration did not alter tissue RNA content but diminished translational efficiency in muscle (43%) and liver (24%). Hepatic eIF2B activity was decreased 24% in alcohol-treated rats, and this was associated with a 95% increase in eIF2alpha phosphorylation. However, alcohol did not alter the amount of 4E-binding protein 1 (4E-BP1) bound to eIF4E, cIF4E bound to eIF4G, or the phosphorylation state of either 4E-BP1 or eIF4E. In contrast to liver, neither eIF2B activity nor the phosphorylation of eIF2alpha was affected in muscle of alcohol-treated rats. However, acute alcohol intoxication increased binding of 4E-BP1 to eIF4E (113%), decreased the amount of cIF4E bound to cIF4G (81%), and decreased the amount of 4E-BP1 in the phosphorylated gamma-form (77%). The plasma concentrations of insulin and insulin-like growth factor-I were unchanged by alcohol, but muscle insulin-like growth factor-I messenger ribonucleic acid abundance was decreased 35%. CONCLUSIONS: These data suggest that acute alcohol intoxication decreases translation initiation and protein synthesis in liver and muscle via different mechanisms. Changes in eIF2B appear to predominate in liver, whereas alterations in eIF4E availability appear more critical in skeletal muscle for controlling translation initiation.

Someone, I think my Dad, told me that just drinking 1 beer can totally eliminate the benefits from 1 workout. I don’t drink because I think its disgusting, but that’s a pretty funny thing. Especially after seeing that one guy’s post about having a “few” Martini’s a day .


Actually, I heard that drinking needs to be compared to the theory of survival of the fittest. You see when you drink, the slowest and weakest brain/muscles cells get killed of. So whats left, the stronger cells. This means the more you drink, the stronger and smarter you will get. Ex. Homer J. Simpson

I don’t drink. No worries for me. I love wearing my Testosterone shirt to places where people are drinking (clubs, bars). Then I can sit back and smile while all the guys’ testosterone levels go down, while mine is good to go! :slight_smile:

Man, that’s depressing. I need a drink.

Well that does it! The surgeon general should be putting a little picture of the 4E-BP1 with a caption that says “Consumption of alcohol decreases the amount of 4E-BP1 in the phosphorylated gamma-form by 77%.” I know it would scare me away from that pint at the bar! Just jokin’ with y’all, I hate drinking too(even more thanks to these drunk rats). Although theres a time and place for everything.

That’s hard for me to believe. I am a pretty dedicadted to working out. Lift 4 times per week and cardio 3 times per week. I am 6 feet tall, 225 lbs with 11 percent body fat AND yes I go out with the boys 3 or 4 nights per week. Most nights we will probably have somewhere between 6 to 10 drinks. I guess you could argue that I would have even better results if I didn’t drink alcohol but I personally would find that pretty boring.

Sometimes you just have to say fuck it.