NDT works better than levothyroxine (cause it contain both t3 and t4 and other stuff) but t3 sustained release works the best, (i don’t know if the other stuff in the NDT have any other benefits i didn’t find any studies that says that NDT patients feels better than on t3 or if there is any reason why it would).
my reasoning is t3 decrease “reverse t3” (inactive form of t3 which binds to the receptors instead of active t3), and t4 increases it which causes symptoms,
so pure t3 liothyronine will be a better replacement but you will have to take the sustained release every 12hours or the regular one(instant release) i think every 8 hours (not really sure about the half life for the instant release) and it peaks instantly so it might cause hyperthyroid symptoms so you will use lower dose and maybe more frequent,
which as you know you have to take t3 on empty stomach which sucks if you ate before bed time and you forgot your night dose(my doctor told me to wait an hour before eating i guess sustained release takes longer time to absorbs),
i take 60mcg “t3 sr” twice a day and i think i can increase more but my lab says other wise, now i have low rT3 and almost out of range high normal t3 and i have high blood pressure and resting heart rate but there is at least 10 different reason why and i dont really have any other symptoms of hyperthyroidism so we will wait couple of months before we changing anything,
now i cant really say i feel better but im sure once i stopped levothyroxine for a week i felt lot better even without any other medication(i felt like im overdosing on something i felt unconscious, i couldn’t concentrate on anything even with my vision i crashed couple of times in one month which i blame most of it on levothyroxine when i have been driving for atleast 5 years and never something similar happened before taking it, its hard to explain what i felt it was so weird),
when i started taking t3 and titrating to 60mcg i didn’t feel any difference but then i ran out of 60mcg i went to lower doses and wasn’t taking them daily so when i went back on 60mcg immediately and took guanfacine for add and high blood pressure i started to feel a difference but not sure if it temporary like always or placebo cause i still have some symptoms my doctor think it could be Lyme disease or something else so i cant really tell you anything for sure but its now eaiser to wake up and get out of bed and now i have motivation to live another day but im stuck with bad habits so im not really doing anything with my day other than going to the gym and school literally it been more than a year so im not sure how long it will take me to realize i can do more with my time and my start living my life normally again(i still sometime feel drops in energy and going to sleep couple of times a day for long time some times as much as 16 hours of sleep but it is better as long as i don’t exhaust my self i can get away with 6 hours of sleep a day).
while levothyroxine works for 20% of the population i think that’s what the statistics says, it doesn’t work for most cause of reverse t3 which doctor not just don’t test for but most don’t know it exist my previous doctor thought i meant t3 uptake so he ordered the wrong test that’s when i realized the thing he said to me was a lie like he treats patient based on symptoms not labwork and that he would changes my meds if i don’t respond well.
you should not ignore hashimoto and antibodies, i have been taking ldn 4.5mg (Low-dose naltrexone is it off label medication its kinda still experimental i guess but it works for lots of stuff including hiv but you will probably wont find a doctor who will prescribe it ) for maybe 2 months and i saw slight decrease in the lab works i would say less than 15% but its gonna take long time i guess (i havent been taking it regularly) or i might need to find the cause first my doctor have couple of theories why i got hashimoto one theories is its a combination of couple of viruses that i tested positive for and false positive for lyme disease and other things that weakens my immune system.
hashimoto needs different treatment than your thyroid meds and iodine helps sometimes alot but its not a cure its a supplement to keep it from getting worse
high shbg is another issue clomid might not work for you, do you know your e2 level?