Let’s say, hypothetically speaking, someone on TRT has a T level of 1000. His identical twin brother has a natural T level of 1000. Will there be any difference in muscle building potential, muscle proteïne syntesis and/or body composition after some time?
In other words; provides TRT benefits over natural T levels regarding body composition and excersise performance?
Define “1000” (assuming you are referring to 1000 ng/dl) with TRT vs “1000” natural.
As properly measured 1000 natural would be peak. 1000 on TRT could be (often is) trough. Is that trough with weekly injection, E3.5D injection, EOD injection, ED injection?
The mean TT levels for those 4 TRT cases are different and considerably higher than the mean natural levels by 30 to 100%+. Typical mean level for a natural with 1000 peak would be 600 to 800 ng/dl.
Important to define properly. Hence “1000 TRT” would likely give much more area under curve than “1000 natural” and why some guys get considerable side effects on “TRT”. They also carry more muscle with same bodyfat level (positive or negative depending on how you look at it).
Hence don’t confuse your natural peak with your TRT trough. Very different animals.
More info to convert between peak/mean/trough level on injectable T cypionate:
Hourly variation in TT level for natural:
Obviously treatment above changes with different T delivery method and its pharmacokinetic profile.
In short, Yes the way TRT and TOT is often done today.
Why would properly measured 1,000ng/dL natural be his peak testosterone? Would the mean be a better representation? (Assuming normal distribution over time)
Exogenous testosterone is known to have a natural decay characteristic, so measuring at the trough is best for controlling the minimum. But what about the peak?
Do we know how endogenous testosterone varies? What are the cycle times? What does the distribution look like during a cycle of natural testosterone release? What is the peak? Low? Mean? Standard deviation?
In other words, let’s make the comparison as close to apples-to-apples as possible.
Go look over the thread I shared above on diurnal variation for endogenous T production. You gotta do a little work if you want to educate yourself. I put it all there for you; you just have to click and read.
Your comment does bring up a good point on old vs old men and their endogenous peak to trough ratio. Typically much less variation in older guys. TT tested in early morning as that is where TT peaks in human male.
I agree we should but that is not how the data is measured and presented so difficult for the laymen to make the apples to apples comparison.
I agree for same mean TT/fT with or without TRT then anabolic potential should be closer to parity. Intent above was to daylight how 1000 on TRT can be very different than 1000 natural with respect to mean TT (given the way measurements are typically done)
Why assign natural with a 1,000 peak, and not also with the TRT person?
Give them both the same peak and compare the means and areas.
Give them the same means and compare areas
Nonetheless, as I understood the OP question. He was considering twins with the only variable being one was relying on his own testosterone and the other was using exogenous testosterone. The only way this question makes any scientific sense is if the twins were accessing the same amount of testosterone.
Let me express the method I approach problems. First I check all assumptions. I require them to be as close to unquestionable as possible.
I had a good work friend who was one of the most logical people I worked. He could logically prove most anything he wanted. His flaw, which almost no one saw, was that in his argument there was at least one faulty premise. He and I argued tooth and nail. His logic was flawless, yet his premises might not be.
Anyone without a genetic disorder can build muscle.
Very few, and I do mean very few, can gain as muscle as they wish. (Note: I acknowledge many say they don’t want as much muscle as is demanded to be on the Olympia stage. I don’t include myself in that group.)
Will there be any difference in muscle building potential, muscle proteïne syntesis and/or body composition after some time?
At pinpointed instant of time … no. As others have stated natural t levels will fluctuate a great deal versus controlled TRT. That aside… no. And @systemlord is correct that some just don’t have the genes for it. For example my biceps lack but my shoulders and triceps ar large. I have poor outter pec insertions but great inner. Point being some guys have poor all around genetics for muscle building and not just weak points.