Could be, but again, until you get familiar with true failure, not necessary. Depends what you have in your home gym, but the first time I did any HIT work, many years ago, I simply started my leg workout with leg extension. Worked up to a top set of 10-15, with slow eccentrics, and until I couldn’t move the damn thing for another rep. So before I had a bar on my back my legs very jelly already.
If you do DC, you will only need to kill a muscle once in a workout.
If you do something closer to what Dorian Yates did, you have to learn to do it, 2-3 times. You kill your legs on a leg extension, then kill them again on the squat, going as close to positive muscle failure as you can without significant technique breakdown. Then on the leg press or hack squat once again. Then you gotta do it on about 2 different hamstring movements, and again for your calves.
It is mentally and physically draining to hit that grinding, painful muscle failure when the last rep takes 5-8 seconds to lift up despite your intention to explode on the concentric. Don’t rush into spicing it with direct pre-fatigue, meaning immediately from isolation to compound. Take a few months, even a year, and get yourself used to repeating that muscle failure on every exercise. If it’s too much, cut the volume by cutting out an exercise. Don’t even worry about back down sets, maybe only with autoregulation. If you didn’t feel like you hit the muscle well enough even though you reached failure, its worth dropping some weight and reaching failure in another set, with more concentration on using the right muscle. Otherwise, hit failure, next exercise.
Again, this is all from my experience, it’s up to you what you end up doing