Thanks my friend...as always your ideas help me to start new searches...
1) About INACTIVE INGREDIENTS....
Well, it is interesting what you say about the inactive ingredients of the testosterone possibly inducing some sort of anaphylaxis...however, I dont think that is the case. Let me explain. I have had about 5 attempts to start TRT and all of them have failed because of high estradiol (measured in a lab, not an assumption) including the first attempt carried out with Proviron. Then it came Sustanon 250, then Lento Martone (national brand, I do not know the inactive ingredients) and Primo teston (bayer). With Proviron the first two weeks were fantastic: increased 5 pounds of muscle weight (hungry all the time), high energy, high libido...nirvana, nothing less....but two weeks later it came the crash: hot flashes, lack of energy, lost of muscle, etc. and high estradiol (Measured in labs). All other episodes: the same (estradiol measured). So in essence, if the ingredients were the culprits why the Proviron increased the estradiol, and more importantly why it always comes with high estradiol (not a symptom of anaphylaxis)...What do you think?
I found a theory about cortisol downregulation quite interesting (a guy called chilln), which I present later, but my labs do not agree with it I guess (see lab results of thyroid and adrenals below)
2) Regarding the AST ALT These are my results:
AST: 15.1 (aug. 2010) 18.1 (june 2013) (0.01-38)
ALT: 15.8 (aug. 2010) 38 (june 2013) (0.01-41)
I guess they are Ok enough to think my liver is working decent enough cleaning toxins...
3) Regarding "low neutrophils high Lymphs ":
- have you been screened for chronic viral diseases, auto immune diseases etc
- any exposure to tropical diseases
I really feared this one, and I have no clue whatsoever...do you have candidates for the chronic or auto immune or tropical which could cause this low neutrophils high Lymphs results? How to proceed here? I can tell you no HIV here (already tested).
4) Regarding Thyroid and Adrenals...
Ok, so in essence I was thinking it may be a thyroid problem or adrenal problem and this is because I read a guy called chilln that says something like this (his theory, not mine, but I have to admit appealing):
WHAT EXACTLY IS CAUSING HORMONES TO GO TOO LOW ? (CHILLN FROM ALLTHINGSMALE, NOT MINE)
a) First and foremost, genetic aging causes a relatively large downregulation of our overall metabolsim, specifically by downregulating our cortisol-production-line (includes pregnenolone, progesterone, and cortisol)
b) Even if we manually force maintain our cortisol-production-line at a more youthful throughput, our genes still downregulate our overall metabolic rate by downregulatig our thyroid hormones T4 and T3 to a lesser degree than it would downregulate our cortisol-production-line.
c) If we allow the gradual downregulation of our cortisol-production-line, this feeds back on our liver, which ramps up our LDL cholesterol ! Our liver has the capacity to detect too low pregnenolone (independant to ACTH) and ramps up synthesis of LDL cholesterol in preparation for that LDL cholesterol to be used as raw material to synthesize pregnenolone. But too little of the LDL cholesterol is synthesized into pregnenolone, leaving LDL cholesterol too high.
d) If we allow the downregulation of our cortisol-production-line, this causes too low cortisol, and since we use cortisol as our primary downregulator of our T (testosterone) metabolism, this means T metabolism would be upregulated if the body didn't take evasive action. But our T metabolism is extremely tightly controlled, and this becomes obvious when our body switches from using cortisol to downregulate our T metabolism, to using high levels of E2 to downregulate our T metabolism.
e) High levels of E2 don't provide the optimum neurotransmitter mix from our previously high levels of pregnenolone, and the neurotransmitter mix from high E2 contributes heavily to erectile dysfunction.
f) Even if we force restore our cortisol-production-line, and reduce our E2 back to optimum levels, the number of our testosterone producing leydig cells in our testes are also gradually reducing (not known if this is due to damage or genetic downregulation).
Reduction in leydig cells reduces our pregnenolone, progesterone, DHEA and T but not our E2 (explained above) In order to maintain T metabolism, our body upregulates the synthesis of T into DHT. DHT is more strongly androgenic than T.
g) Gradual downregulation of GH (growth hormone) HERE ENDS CHILLN QUOTING...STARTS ME AGAIN:
So I proceeded to have tests on my thyroid and adrenals (not salivary, not available here):
Thyroid (July 23, 2014)
TSH 2.0 miu/ml (0.4-4.2)
fT4 1.6 ng/dl (0.8-2.0)
fT3 2.9 pg/ml (2.1-4.7)
thyroglobulin antibodies 22 ui/ml (<120)
thyroid peroxidase antibodies 17 ui/ml (<34)
Adrenals and related (July 23, 2014)
Progesterone: 0.5 ng/ml (<0.8)
Cortisol A.M (8:00am) 13.5 mcg/dl (5.0-25.0)
Cortisol P.M (4:00pm) 12.3 mcg/dl (2.0-12.0)
ACTH (8:00am) 78.7 pg/ml (20.0-100.0)
ACTH (4:00pm) 42.4 pg/ml (20.0-100.0)
17-ketosteroids 9.1 mg/dl (12.0-38.0)
Estradiol 17.2 pg/ml (<54)
SHBG 33.0 nmol/l (13.0-71.0)
Besides, I had to monitor my glucose for 10 consecutive days 6 times a day with a glucometer:
Before breakfast: 110, 116, 123, 104, 110, 110, 118, 112, 110, 117
Two hours after breakfast: 123, 112, 110, 102, 109, 111, 118, 103, 121,110
before lunch: 106, 107, 111, 118, 101, 110, 110, 116, 110, 113
Two hours after lunch: 94, 119, 101, 115, 99, 99, 117, 98, 94, 121
before dinner: 97, 97, 118, 103, 108, 112, 108, 110, 105 (missed last day measure)
before going to bed: 133, 108, 125, 126, 103, 117, 129, 142, (missed last day measure)
So in general I dont see anything really, really abnormal about the thyroid or the adrenals that could really validate chilln downregulation of cortisol that could be turning estradiol as the mechanism to upregulate T...which left me again lost in space...what is causing my excessive T--->E2 conversion that is turning my life in hell?