I finally had my Defy Medical consultant yesterday and it went better than I had expected, Dr. Saya is in a league of his own for sure. Dr. Saya hit on important points that were never covered before with my previous endocrinologists.
We discussed my previous protocol (50mg twice weekly) that was responsible for my initial labs below, that the 677 range was likely supraphysiological for me since it causes acne all over my body, even in places I never knew one could get acne.
We agreed the high E2 is causing problems with mood, therefore periodic irritability/stress together with my 7 months long chronic cough is likely responsible for my elevated Reverse T3, so balancing estrogen and reducing insulin resistance is critical to bringing down Reverse T3 naturally because the main thyroid hormones are good.
A1C has lots of room for improvement and IGF-1 is a little lower than Dr. Saya would like, so we discussed peptides, 300mcg SQ injection of ipamorelin to increase growth hormone naturally.
I’ve been on a new protocol for the past 4 weeks, 16mg EOD (64 weekly) and noticed muscles were getting noticeably firmer after only the second week. Muscles are continuing to get firmer every week, muscles are stiff and sore 24/7 and that feel good burn you get after a workout is constant all without the workout.
I went ahead and ran blood test at the 4 week mark (today) so Dr. Saya can dose the AI properly rather than going by outdated numbers from my old protocol. I don’t plan on being on the AI for long, after I lose significant weight I’m going to stop it and see how I do. Most guys after losing significant weight can reduce or drop the AI completely since aromatase enzymes lives in fat tissue.
My erections are starting up again as I draw nearer to the 6 week mark on my new protocol, testicles are tingling with sensitivity on and off throughout the day. I’m going to start berberine 500mg twice daily in place of Metformin since I have a negative reaction to it, coughing and hoarseness.
Going to take fish oil daily as well. I’m going to try everything suggested without HCG for right now. We are going to reassess thyroid in three months and recheck thyroid with another full thyroid panel. We are also going to do a 4 point cortisol saliva test.
Dr. Saya said one hormone out of balance is all it takes to cause a domino effect, high E2->emotional imbalance-> stress -> high heart rate-> high blood pressure. All of these broken systems can wreak havoc on many different hormones.
I’m going to start eating 80% whole foods, Steak, fish, eggs, veggies and some fruits. I will refuse to eat past 6pm, maybe raspberries/strawberries for snacking.
I’m very pleased with my consultation and look forward to my next check-in in 3 months to see what progress I have made.
I’ll update labs earlier next week and by weeks end I should know AI dosing.
Previous protocol = 50mg twice weekly.
Total T = 677 ng/dL 264-916 ng/dL
Free T = 29.2 pg/mL 6.8-21.5 pg/mL
SHBG = 16.2 nmol/L 16.5-55.9 nmol/L
Sensitive E2 = 70.6 8.0-35.0 pg/mLTSH .902 0.450-4.500 uIU/mL
Free T4 1.37 0.82-1.77 ng/dL
Free T3 3.6 2.0-4.4 pg/mL
Reverse T3 22.4 9.2-24.1 ng/dL
Thyroglobulin Antibody 1.1 0.0-0.9 IU/mL
Thyroid Peroxidase (TPO) Ab 10 0-34 IU/mL
Hemoglobin 16.7 13.0-17.7 g/dL
Hematocrit 48.8 37.5-51.0
RBC 5.58 4.14-5.80
DHEA-Sulfate = 224.1 - 71.6-375.4 ug/dL
Cortisol = 14.2 6.2 - 19.4 ug/dL
IGF = 153 67-205 ng/mL
Prostate Specific Ag, Serum 1.0 0.0-4.0 ng/mL
Magnesium, RBC 5.7 4.2-6.8