Rob,
Unilateral exercises could be an entire set of articles…lucky for you I’m working on one as we speak! The first will deal solely with exercises for the lower body. Hopefully TC will like it and use it for the mag!
As far as sets, reps and rest intervals, I would start out with higher reps (8-12) and a higher TUT to try and improve motor control. Obviously, you will want to start off with the weak side first. Even if you have to start off with a 3-1-3 tempo, make sure that you are using the muscles you want to use. Rest intervals don’t need to be huge (60-90 seconds), simply because you’ll also be getting rest when the opposite side is working. I would do 3-4 weeks with this set/rep scheme, and then start focusing on more neural-based adaptations in a lower rep-range.
If you are interested, you might also check out Ian King’s limping series. He gives several unilateral exercises for the lower body, as well as protocols for addressing varying degrees of muscle imbalances. For instance, if you are X% stronger on one side, you will perform Y more reps on the opposite side.
Hope this helps!
Stay strong
Mike