T Nation

MTOR Thresholds & Diminishing Returns


#1

CT - When combining mTOR pathway activators in the same workout, do you know/think there’s a point of diminishing returns?

For example, if you supplement micro-PA and leucine pre-workout, then perform a layers workout with eccentric work, and end with EQIs… Do you suppose there is a point where the switch has been flipped as much as possible, the pathways are activated, and there’s no point to doing everything at once?

Could some of that effort, time, or money be wasted and we have no way of knowing? Or do each of these activate parallel pathways that are complimentary and produce compounding effects?


#2

[quote]D.E.N.N.I.S wrote:
CT - When combining mTOR pathway activators in the same workout, do you know/think there’s a point of diminishing returns?

For example, if you supplement micro-PA and leucine pre-workout, then perform a layers workout with eccentric work, and end with EQIs… Do you suppose there is a point where the switch has been flipped as much as possible, the pathways are activated, and there’s no point to doing everything at once?

Could some of that effort, time, or money be wasted and we have no way of knowing? Or do each of these activate parallel pathways that are complimentary and produce compounding effects?[/quote]

We have no way of knowing at the present time. Even if the switch has been turned on maximally it doesn’t mean that the other work done wont add to the growth stimulus though.