Per Defy’s suggestion as my E2 is up in the 60s 8 weeks into TRT and me not being fond of the idea of jumping to Anastrozole, they have suggested that I move from twice per week to three times per week to try and lower E2 (my SHBG also went from 67 to 37). Should I consider lowering my dose slightly? I’ve read about some guys needing less total weekly dosage amounts when moving to more frequent injections.
Ive been at 80mg twice per week. A 1:1 change would now be 27mg three times per week. Not sure if I should dial that down slightly so i truly see the benefit of lowering E2 (without losing too much T).