I wanted to see if any anastrozole over-responders here have had success in microdosing the drug.
I’ve been put on 120mg/week TE with 350 HCG 3 x per week. Pre-intervention, I had a total T of 330 ng/dl, and Total E of 24 pg/ml. Other numbers, keeping in mind I live in Canada and don’t have access to the full blood panels my friends south of the border enjoy.
Dehydroepiandrosterone [DHEA-S] 8.2 umol/L
LH: 3.1 IU/L
Prolactin: 10 ug/l
Thyroid Stimulating Hormone [TSH] - 1.71 mIU/L
Thyroxine Free [Free T4] 11 pmol/L
Triiodothyronine Free [Free T3] 4.8 pmol/L
My reading here has led me to believe that Iodine deficiency can be a major contributing factor to poor TRT results, and my thyroid numbers all came back “within range” but often on the lower end of that range, so I’ve been supplementing with a daily thyroid support pill that has 150mcg Iodine, Selenium, and several other compounds. I’m usually on the “perpetually hot” side of the spectrum and my outer eyebrows are bushy, so I don’t think this is causing an issue, but i figured better be safe than sorry.
6 weeks after beginning T-replacement with HCG, my Total T went to 904, but my Total E jumped up to 46. I felt amazing from about week 2 to week 5, but then started getting nipple sensitivity, irritability, etc.
The doctor put me on 0.5mg Anastrozole 2x/week. The side effects were awful - severe anxiety and irritability (worse than when i had high estrogen) and achy joints; particularly knees. Tried lowering this to 0.25mg 2x/week, and not much better. Unfortunately I did not have the ability to get blood tests during these two regimens to see what effect it had on my estrogen levels, again based on my Canadian geography.
I think its fair to say that I’m an Anastrozole overresponder, and even if i’m not i simply can’t tolerate the side effects of it, but I also clearly need some type of estrogen control.
My question: have any other anastrozole overresponders had success in microdosing? I’m considering dissolving 3mg anastrozole in 30ml Rye Whiskey (real scientific like) and using a syringe to measure out 1ml doses (0.1mg) or even 0.05ml doses (0.05mg) and trying it, and i wanted to see if anyone else has given this a shot?