T Nation

Metformin HCL and muscle synthesis


#1

It has been suggested that Metformin blunts muscle synthesis, but I can't find anything conclusive. Does anyone have any experience or knowledge about this? (Bill Roberts?)

I am somewhat insulin resistant, but not diabetic. I use Metformin before eating starchy foods to improve glucose uptake and nutrient partitioning, and I was considering using it for nutrient partitioning while cutting weight.


#2

In practice I don’t think it’s an issue: Metformin has been used to improve body composition at least since Dan Duchaine recommended it back in the 90’s, and has worked fine.

On the science, a couple of things suggest improving muscle protein synthesis, at least where there’s a burn injury:



Now, the burn state could be different.

I don’t know of any scientific evidence showing reduced muscle protein synthesis with metformin.

Personally I wouldn’t worry about it: it works well in practice.


#3

Awesome Bill. Thank you for your help.

Your posts in these forums are of great value; I always check out a thread if you have posted in it.


#4

Thank you! Glad to be of any help!