I no virtually nothing about Organic Chemistree apart from how to spell it.
So I'm guessing here, so please don't kill me if it's bs.
I've done a lot of reading on the human cytochrome. There's an ever growing list of around 3000 different enzymes which metabolize different substrates.
Some substrates are promiscuos, they will quite happily dock with the active site of more than one enzyme.
Some substrates inhibit the enzyme as they are metabolized.
Some substrates having a longer dwell time whilst docked.
I've heard and read that everybody has a different enzyme profile so I guess that's why some things work for some and not others.
I can't find which enzymes metabolize the substrates in the post, but it may be that some combo's overload certain enzymes.
Sorry if you guys new this already