Why are certain oral steroids more toxic than others? Say I take 10mg of oxandrolone vs. 10mg methyltestosterone vs. 10mg stanozolol, they don't have the same toxic effect on the liver even though they are all C-17 methylated.
Is it just the structure of the molecule itself that makes it harder/easier to demethylate it? From my background in organic chemistry the difference in hepatoxicity wouldn't seem to have the magnitude that it does due to this. Anyone have more insight?