I was the biggest I've ever been in college and was in a fraternity and playing college athletics, both of which involved a heavy dose of partying (4+ nights per week).
Work hard to play hard. Go all out in the gym, go all out in your social life, that's what college is for and you best take full advantage of every minute you have there.
The best part is, after having gone all out in my four years of college, it's all out of my system, and I'm fully focused on the next stage of my life.
(I graduated with a double major and high honors, so I wasn't just skipping classes either to make up for it)