It sounds like there were a lot of issues and probably both parties were depressed.
He would have had low energy and some depression from the marriage and the low T. Other health issues add to the fire and thyroid problems seem common in TRT guys and candidates.
I suspect the TRT, if it working already, has enabled him to do things that he did not have the energy to face earlier.
How long has he been on TRT now?
If his E2 [estradiol] levels are increased too much, very typical, that would make him bitchy and intolerant. Guys get moody too.
I have not seen a post of this nature here before. We do see that TRT improves men and their moods, restores sexual intimacy. We see some men driven to TRT because low T threatens the marriage, not the other way around. But some men with restored sexuality, which can be very strong at first, may wander if their wife/GF is not willing to participate. Sometimes its the wife/GF who drives the man to the doctor because of the sexual performance and intimacy problems. With restored sexuality, some women have a hard time adjusting to the changes. So there can be women hungry for more sex and others who have difficulties with the increased sexual demands. In any case, its very dynamic and both parties are not fixed entities and evolve.