Marijuana Smoking vs Cannabinoids for Glaucoma Therapy
JAMAVol. 116 No. 11,
It is undisputed that smoking of marijuana plant material causes a fall in intraocular pressure (IOP) in 60% to 65% of users which can benefit sufferers of glaucoma
Does Marijuana Use Cause Long-term Cognitive Deficits?
JAMAVol. 287 No. 20,
May 22/29, 2002
Both of these laboratory studies found minimal cognitive deficits after marijuana administration in experienced users and suggest that recent marijuana use is a minimal confounder in experienced marijuana users. Data from well-controlled laboratory studies in combination with data from retrospective studies can ultimately provide a more comprehensive view of marijuana-related effects on human cognitive performance.
Therapeutic Marijuana Use Supported While Thorough Proposed Study Done
JAMAVol. 281 No. 16,
April 28, 1999
The investigators said the data suggest marijuana may help with pain relief, nausea, and appetite stimulation….“Marijuana’s potential as medicine is seriously undermined by the fact that people smoke it, thereby increasing their chance of cancer, lung damage, and problems with pregnancies, including low birth weight,” Benson said. “For that reason, we do not recommend smoking marijuana for long-term medical use. While we see a future in the development of chemically defined cannabinoid drugs, we see little future in smoked marijuana as a medicine.”
Marijuana and Glaucoma
JAMAVol. 116 No. 11,
Where do marijuana and the cannabinoids fit in? Since our present therapy is directed only at lowering IOP, we must ask whether marijuana lowers the IOP. The answer in humans is an unequivocal yes. Several good studies show that smoking a marijuana cigarette reduces the IOP in normal subjects from approximately 15 to 11 mm Hg, a 24% reduction. The Goldmann equation indicates that the higher the IOP, the greater the IOP-lowering effect for a given suppression of fluid formation or enhancement of fluid drainage. In a group of patients with glaucoma and ocular hypertension, with starting IOP of approximately 30 mm Hg, smoking a similar marijuana cigarette decreased IOP to approximately 21 or 22 mm Hg, also a 20% to 25% reduction. This result is comparable with that of other glaucoma medications, including the recently approved ones.
I have not been able to find any studies showing a decrease in testosterone, however, from I have found any studies that supposedly showed this were conducted in adolescents. The truth is, marijuana clearly has a place in medicine, however, because of the stigma attached, there are very few studies geared towards finding a use or examining any possible benefits…much like steroid use. Steroids decrease circulating testosterone by the way, so I would assume that someone worried about this effect would stay away from those as well. There is a cancer risk from smoking it which is why some groups are trying to find ways around that problem by ingesting it instead. Marijuana is an illegal drug so that should be the defining factor, however, it appears to be no more harmful than LEGAL alcohol and cigarette smoke, both of which are chemically addictive while marijuana has proven not to be. -Professor X