Read the package insert. Yes, must be refrigerated.
Shots: How often are you injecting? If once a week, inject more often and that can reduce T spikes and the E problems that follow. You can inject twice a week, or every 3 or 2 days [E2D=EOD, E3D]. With steady D levels, you can get an adex dose that matches a steady amount of T.
EOD T, hCG and adex all work well if the routine is something that you can live with.
Your recent labs were between injections or?
7 drops of adex should take you to E2=21-22pg/ml.
You have test cream now? If you switch to transdermals, it will be a while before you know what your T levels are and make adjustments. Meanwhile the cream may create disproportionately more E. You will then not know what your E2 is and may be off target with adex.
When you add hCG, your T will go up a bit and E may increase as well. More moving targets for adex. Not that these things can't be managed, just things to be aware of.