Thanks for the answers @systemlord … sharing some my past experiences here in the interest of finding some answers / protocols that worked for ppl like me.
6ft, 210pounds, 40yrs.
Starting params before TRT:
TT: 145 ng/dL
E2: 26 pg/mL
SHBG: 19 nmol/L
FT: didn’t do it at this time.
IGF1: 131 ng/ml
LH: 4.1 mIU/ml
TSH: 1.41 μIU/ml, Free T4: 15.4 pmol/L
Symptoms (for about 5 yrs): mild depression, no interest in work, lack of Libido.
I tried weight training - 1hr training = 4 days of soreness and at-least 3 days of outright not being able to get out of bed or go to work.
Fired from 2 jobs for not taking initiative etc.
Started TRT in 2019.
Protocol 1: Androgel for 3 months.
Massive energy and mood swings. Massive water retention. Felt worse than non-trt.
Protocol 2: Nebido 1000mg IM shots once in 2 months.
Massive mood and energy swings. By 4th week felt Low T symptoms. Discontinued after 6 months and 3 shots.
Protocol 3: Combo of T.Enanthate 110mg + T.Propionate 25mg
Started with IM shots every 5 days (135mg). + 0.5mg AI EOD. Worked much better than above 2 protocols.
Titrated, settled on 15-18mg daily subQ injections + 1mg AI (Arimidex) EOD. >> got best results in this protocol. (TT: 800 to 1000, E2: 10 - 20,SHBG: < 20 … I do labs almost every 4 to 6 weeks.).
BUT whenever I did weight training or cross fit, I was sore for 3 days and low T mood & energy for 2 days. This was like clock work. If I injected additional 15mg for 2 days after weight training, then low T and soreness were MUCH MUCH lower.
Protocol 4: T.Cyp 1+ yr (moved to a diff country and above med was not available)
T.Cyp started at 150mg weekly + 1 AI EOD = bloated and not good results.
Titrated & moved to 20mg daily subQ + 1mg AI EOD. Kind of reached a mood + energy plateau that was ok but not as good as protocol 3. (TT: 800 to 1400, E2: 10 - 20, SHBG: < 20).
Same observations wrt to weight training. On night of training day & next day, inject 15mg more to feel normal. If not soreness and low T mood & energy symptoms.
Protocol 5: T.Cyp+T.prop (80% 20% combo)
20mg SubQ + 0.75AI EoD. (TT: 800 to 1000, E2: 10 - 20, SHBG: < 20).
Feeling better than protocol 4 & equal to protocol 3.
Same observations wrt to weight training - inject 20mg more on day & next to reduce low T mood & energy.
Narrowed E2 build up, Tprop affinity, daily small injections etc to low SHBG (forum reads & consulted with Defy medical docs too).
So my observations:
Ai - must have about 1mg EoD. Without that bloat like a baloon.
Tprop seems to help better than long acting esters like Cyp.
SubQ daily injections = way better than EoD or weekly.
Weight training = inject 15-20mg more for 2 days to get relief.
Puzzle = Why do I need extra T injections when weight training. Am I excreting a lot or some other physiological processes that I don’t know?