Quick question for you guys: If someone has low SHBG (<12 nmol/ml), does that mean that the 'preferred' normal E2 value of 22 nmol/ml could be too high since E2 also binds to SHBG? I mean, does it work the same way it do with T, and this makes more free E2 circulating?
I'm asking because my SHBG is always between 10 and 12... and I've been struggling with high E2 symptoms even if I take .5 Arimidex EOD and get my E2 near 22 nmol/ml.
BTW, I'm not on T injections, only HcG monotherapy at 500iu EOD with 0.5mg anastrozole pill EOD. Haven't succeeded yet in convincing my Endo to give me a T cyp script...
Anyways, this got my Free T at 500 pmol/L (223-915pmol/L) but I'm clearly not feeling better and still has all the symptoms of Low T and High E2 (metabolic syndrome, fatigue, gyno, brainfog, etc.)... so I was wondering if my low SHBG could have something to do with this.
Thanks in advance!