My experience when I went from exclusively high bar to using low bar for a meet last year:
It's going to feel uncomfortable for a couple weeks.
Set the bar on your back tight and when you lift off make sure the weight is set on your back and not your wrists.
"Fall forward" from your hips a little more than you would with the high bar. Feet apart with a little more width.
If your wrists really bother you, use wraps for all sets, but gradually start to take the wraps out of warm ups and lighter sets and reserve them for heavier weights.
If you hit it right the movement should still feel natural, though the wrists and bar placement may take time to get used to. Just because you switch to low bar doesn't mean you have to do a Stan Efferding super wide glute/ham squat (google if you don't know).