T Nation

Letrozole/Femara


#1

Something I'm having trouble understanding, was hoping someone could clear this up for me.

If estrogen is crucial to bone maturation and growth in puberty, how does a substance that is capable of reducing estrogen levels by 98% help to increase growth in adolescents?

I understand that estrogen is responsible for closure of the growth plates at the end of puberty, but from what I've read it suggests that inhibiting the estrogen levels so harshly enhances the growth of adolescents that would otherwise have a shorter adult height.

Am I missing something else that Letrozole acts upon?