T Nation

Letrozole Best of Both Worlds?


#1

First off, thanks for your wise input on this question.
Recognizing the AI benefits, and LH stimulatory effects of Letrozole,would it be possible, or is there any experience in using a reduced dose (say .5 mg twice weekly) to harness the benefits of hCG and anastrazole. It would appear a clever short cut.
Just a thought as I would like to avoid SERM meds and stave off testicular atrophy without hCG. Nothing against hCG but FDA regulatory changes may make it increasingly difficult and expensive to acquire;therefore exploring alternative strategies.
Your insights are greatly appreciated.


#2

Letrozole is an AI and its effects are only the result of lowering E2 levels.

With more input on a situation, I often suggest 0.5mg anastrozole per week in EOD divided doses.

Letrozole dose/response is not very predictable and results can be harsh.

The result depends on ones age and HPTA responsiveness. For guys with low T and low E2, lowering E2 will only add to the misery they feel.

When you read the old studies where young normal males were given an AI and T increased, the results do not apply to every other situation.

If it works for you; great!

Obviously the benefits to those with primary hypogonadism are low.