[quote] Brook wrote:
Is it the case then, that the rebound idea is more of a theoretical one based on the non-suicide inhibition - rather than a practical one that occurs during the cycles designed by bodybuilders etc…?
The idea of estrogen rebound was being tossed around as of at least 15 years ago, maybe longer. I don’t suppose it is based on theory, but as an attempt to explain undesired post-cycle side effects from badly-done cycles.
It is possible that there are multiple causes. E.g., perhaps in one cycle the problem is having used Deca for 12 weeks and then being surprised at being impotent for quite some time after that. A steroid author might guess, just out of nowhere, that the problem was from lasting increased estrogen, and the lack of actual data showing that would be unlikely to stop him, in most cases.
Another cycle might have another undesired side effect from a different cause also attributed to increased estrogen.
In still another, maybe estrogen actually is increased, but not as a necessary consequence of doing an effective androgen cycle.
The concept of estrogen rebound was a fairly entrenched one even before aromatase inhibitors became popular. SERMs don’t downregulate the ER, nor does their discontinuance upregulate the ER so far as I know, so that at least is not, I think, a mechanism for traditional claims of estrogen rebound.
Whether possibly there is such an effect now from using an AI and bringing estrogen to a good low-normal level and then discontinuing it and seeing it go to mid-normal, I don’t know.
If there is it seems odd that it would be a major or lasting effect. Particularly as AI’s clear slowly anyway.