T Nation

Letro and HCG

As stated in the AI Section

[quote]Letro: Letrozole is currently the most powerful aromatase inhibitor available. It has been shown to reduce estrogen levels by 98% or more. Intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively.

Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third. Letrozole has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level. Letro is best dosed from 0.125-2.5 mgs depending on the desired effect.[/quote]

Now I was planning on HCG @ 200-250 IU in the middle of my cycle. Having Tren in the mix I’m figuring on Letro as my AI. Now after reading this I’m feeling like I should down the dose of HCG.

Thoughts?

200-250 IU, how often?

If one time, that won’t do much.

If three times per week, that’s a perfectly reasonable and effective dose.

If daily, it’s at the high end but acceptable. It may not yield any more T than half the dose would, though.

Oh… my bad.

200-250 IU e3d

I was thinking with adding the Letro and Letro’s ability to increase LH will the HCG need to be the same or would a lower dose do the trick?

Hey,

If I where you i would try and maybe get my hands on some xenodex, it has 1mg of anastrozole, 20mg letrozole, and 10mg of Tamox in each capsule, they are the best i have ever taken:)

At the minute i am running a 400mg testoviron (1.5ml every six days) with a 300mg deca (1.5ml every 6 days) and it’s keeping me really dry:)

[quote]oliiol wrote:
Hey,

If I where you i would try and maybe get my hands on some xenodex, it has 1mg of anastrozole, 20mg letrozole, and 10mg of Tamox in each capsule, they are the best i have ever taken:)

At the minute i am running a 400mg testoviron (1.5ml every six days) with a 300mg deca (1.5ml every 6 days) and it’s keeping me really dry:)[/quote]

WTF!

How much of that crap are you taking a day?

off the top of my head I think the Tamoxifen messes with the Letro and Adex. Also the Adex @ 1mg should be spread out over 4 days.

i just take 1 eod

[quote]oliiol wrote:
Hey,

If I where you i would try and maybe get my hands on some xenodex, it has 1mg of anastrozole, 20mg letrozole, and 10mg of Tamox in each capsule, they are the best i have ever taken:)

At the minute i am running a 400mg testoviron (1.5ml every six days) with a 300mg deca (1.5ml every 6 days) and it’s keeping me really dry:)[/quote]

WOW! i would like to see you in 2 years and see just how stacked you are dood!

Or shrivelled and depressed…

B

its working great for me, just thought i’d mension it to you .

Drugs like Anastrazole work by blocking the production of estrogens in the body by binding to the enzyme aromatase.

Aromatase inhibitors are more desirable then estrogen receptor blockers like tamox and clomid because they function as true anti-estrogens and do not share the undesirable estrogen agonist activity but when you put them together they work fine, niether one ruins the other.

and 1mg is fine to take eod, so i dnt know were you have got 250mg a day from, i realise that, that is the recomended dosage but trust me its fine.

AI/SERM Sticky

I’m not printing this as a fact. It’s just something I read here on the forums under the AI and SERM Sticky.

I’m not sure, to be honest buddy, i have been taking arimidex on its own for a long time and i feel that the xenodex works really well (better than arimidex) for me so i don’t think that this infromation is 100% correct, or maybe this only happens when the dosage of tamox is increased above 20mg ed. I dont know…

But why would they place the three together in one capsule??

I have no idea, think you should maybe try and get some though buddy… i think they are awesome :slight_smile:

[quote]oliiol wrote:
Drugs like Anastrazole work by blocking the production of estrogens in the body by binding to the enzyme aromatase. Aromatase inhibitors are more desirable then estrogen receptor blockers like tamox and clomid because they function as true anti-estrogens and do not share the undesirable estrogen agonist activity but when you put them together they work fine, niether one ruins the other…[/quote]

So taking an anti aromatase and an estrogen is not an issue? AND is there ANY benefit in taking 3 drugs when just one AI will work just fine?

[quote]
…and 1mg is fine to take eod,[/quote]
Uh… it is a little high actually, on its own it is a little high - only a little. With letrozole it is lowering your estrogen to levels that will be harmfully low.

i realise that, that is the recomended dosage but trust me its fine.[/quote]Recommended dosage of what? What are you talking about?

Trust you? lololololll!

You obviously have copied a large part of that post and are obviously clueless when it comes to dosing AAS and their ancillaries.
You are surprised that you get further estrogen suppression from adding Letro and Tamoxifen than just using Adex alone? Wow, can i borrow the books you read?

Maybe, just maybe ‘they’ put all those in one capsule to charge large amounts to stupid dipshits who think that more is better

Get a grip child. Stop this nonsense. You take what you like and as much as you like - but go talk about it elsewhere.

Brook

[quote]musclemass200 wrote:
Oh… my bad.

200-250 IU e3d

I was thinking with adding the Letro and Letro’s ability to increase LH will the HCG need to be the same or would a lower dose do the trick?[/quote]

The HCG will on its own, independent of LH production, stimulate T production to probably the high normal level.

Without the letrozole, the combination of this testosterone plus the estrogen resulting from an average degree of aromatization would in most cases reduce LH greatly.

With the letrozole, the estrogenic inhibition will be much reduced and so LH should not be suppressed as much. It might well remain in the mid-normal range. I tend to expect so and am following a somewhat similar protocol myself now, but have not had LH tested yet to verify.

I don’t think it’s too much HCG regardless of also maintaining, we hope, normal LH thanks to the letrozole.

lol, brook brook brook… whats your problem you roided up homo!

I shall talk about what ever i like wherever i like, and there is nothing you can do about it!!

I’m simply trying to say that if the guy wants to try arimidex then maybe he should try some xenodex.

You make me laugh because you say things like your the only dick that knows things lol, your really are pothetic… and i think you may have spent too long on here you retard.

“Uh… it is a little high actually, on its own it is a little high - only a little. With letrozole it is lowering your estrogen to levels that will be harmfully low.”

no… its not harmfully high, I may run into a few problems with prolonged usage… worst case i’m going to get high levels of oestrogen when i come off. do you even no what you are talking about?

or do you just regurgitate little bits of what other people say.

hahahaha you idiot,
“who said 250mg?”

1mg over 4days is 250mcg mr know-it-all

did you have a crap christmas or something, is that why you are upset, or have you just been abusing the test.

One of my work friends psychiatrist if you want me to refer you to her… and if you can’t afford the srvices i shall pay for it for you as i do take pitty on you:)

have a nice night you retard, one final thing, why have you not got a picture up of yourself, do you look shit?? maybe thats why your highly strung??

well, night night.

[quote]oliiol wrote:
lol, brook brook brook… whats your problem you roided up homo!

I shall talk about what ever i like wherever i like, and there is nothing you can do about it!!

I’m simply trying to say that if the guy wants to try arimidex then maybe he should try some xenodex.

You make me laugh because you say things like your the only dick that knows things lol, your really are pothetic… and i think you may have spent too long on here you retard.

“Uh… it is a little high actually, on its own it is a little high - only a little. With letrozole it is lowering your estrogen to levels that will be harmfully low.”

no… its not harmfully high, I may run into a few problems with prolonged usage… worst case i’m going to get high levels of oestrogen when i come off. do you even no what you are talking about?

or do you just regurgitate little bits of what other people say.

hahahaha you idiot,
“who said 250mg?”

1mg over 4days is 250mcg mr know-it-all

did you have a crap christmas or something, is that why you are upset, or have you just been abusing the test.

One of my work friends psychiatrist if you want me to refer you to her… and if you can’t afford the srvices i shall pay for it for you as i do take pitty on you:)

have a nice night you retard, one final thing, why have you not got a picture up of yourself, do you look shit?? maybe thats why your highly strung??

well, night night. [/quote]

You are cordially asked to leave this board. Or at the very least never post again until you realize how bad some of the info you post is.

For a surgeon you sure spell like a 16 year old. And btw ‘mg’ is different from ‘mcg’ chief.

This post was flagged by the community and is temporarily hidden.

wow… Totally hijacked!

This post was flagged by the community and is temporarily hidden.

lol… It’s all good and it wasn’t directed at you.

I just checked back in and I thought I was on the Day’s of our Lives website.

MM

[quote]bushidobadboy wrote:
BONEZ217 wrote:
oliiol wrote:
lol, brook brook brook… whats your problem you roided up homo!

I shall talk about what ever i like wherever i like, and there is nothing you can do about it!!

I’m simply trying to say that if the guy wants to try arimidex then maybe he should try some xenodex.

You make me laugh because you say things like your the only dick that knows things lol, your really are pothetic… and i think you may have spent too long on here you retard.

“Uh… it is a little high actually, on its own it is a little high - only a little. With letrozole it is lowering your estrogen to levels that will be harmfully low.”

no… its not harmfully high, I may run into a few problems with prolonged usage… worst case i’m going to get high levels of oestrogen when i come off. do you even no what you are talking about?

or do you just regurgitate little bits of what other people say.

hahahaha you idiot,
“who said 250mg?”

1mg over 4days is 250mcg mr know-it-all

did you have a crap christmas or something, is that why you are upset, or have you just been abusing the test.

One of my work friends psychiatrist if you want me to refer you to her… and if you can’t afford the srvices i shall pay for it for you as i do take pitty on you:)

have a nice night you retard, one final thing, why have you not got a picture up of yourself, do you look shit?? maybe thats why your highly strung??

well, night night.

You are cordially asked to leave this board. Or at the very least never post again until you realize how bad some of the info you post is.

For a surgeon you sure spell like a 16 year old. And btw ‘mg’ is different from ‘mcg’ chief.

+1 from me.

You claim to be a medical professional, yet you apparently don know the difference between ‘know’ and ‘no’.

I call shenanigans. You aren’t a medical professional at all are you?

BBB[/quote]

x2

:wink: