Some doctors prescribe TRT and Metformin for people with diabetes. TSH is indicating the pituitary gland is unhappy with the amount of thyroid hormones, any TSH >2.5 indicating a problem, a sick care doctor would never treat the thyroid with those numbers and so seek a private doctor in anti-aging.
Testosterone is low, but again is not low enough for insurance to approve treatment, again seek a private doctor who doesn’t take insurance. Your uncle is at high risk for developing cardiovascular disease with these testosterone levels. Your uncles testicles seem to be functioning poorly which is probably do to age, LH is healthy, yet testosterone is low.
FSH is above ranges suggesting testicles are just not responding well to either LH or FSH stimulation. Men with low testosterone live shorter lives and tend to have cardiovascular, heart problems and more aggressive prostate cancer.
Testosterone Threshold for Increased Cardiovascular Risk in Middle-Aged and Elderly Men
These data showed that a testosterone threshold of 440 ng/dL was associated with increased Framingham 10-year CVD risk in middle-aged and elderly men. Poor sexual performance, decreased morning erection, and loss of libido had an impact on the testosterone threshold for CVD risk. The threshold level was higher in men with sexual dysfunction.
Reference ranges for TSH and thyroid hormones
First of all the distribution of TSH reference range is not normal, with median values (also depending on population iodine intake) usually between 1-1.5 mU/L. On the other hand, upper TSH reference limit is (assay-dependent) usually around 4.2-4.5 mU/L. There is also an argument that significant number of patients (up to 30%) with TSH above 3.0 mU/L have an occult autoimmune thyroid disease
The evidence for a narrower thyrotropin reference range
It has become clear that previously accepted reference ranges are no longer valid as a result of both the development of more highly sensitive TSH assays and the appreciation that reference populations previously considered normal were contaminated with individuals with various degrees of thyroid dysfunction that served to increase mean TSH levels for the group. Recent laboratory guidelines from the National Academy of Clinical Biochemistry indicate that more than 95% of normal individuals have TSH levels below 2.5 mU/liter. The remainder with higher values are outliers, most of whom are likely to have underlying Hashimoto thyroiditis.