My current protocol: Test Cyp 30mg EOD with 30G 1/2 needle, HCG 250 units SQ EOD. It’s test-hcg-test-hcg. 0.25 mg Arimidex 2 times a week. I have used different dosing templates (one time a week IM, split dose two times a week IM, SQ EOD, etc). I have always had a high SHBG no matter what protocol I use but my current EOD has resulted in the highest increase of SHBG. My Thyroid function, and LFTs are always normal. My HCT gets high but I bring it into the normal range with blood donation.
My labs are the following: Total Test LC/MS = 2006 (348-1197 ng/dL), Free Test=32 (7.2-24 pg/ml), DHT 223 (30-85ng/dL), Estradiol 22.9 (7.6-42.6), PSA 0.7 (0.0-4.0ng/ml), SHBG 85.9 (19.3-76.4 nmol/L). Not great sex drive but can get and maintain an erection, increased body hair, low energy, seems like I’m actually loosing muscle mass. Should I decrease frequency but increase mg per injection?
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SHBG levels increase with estrogenic states (oral contraceptives), pregnancy, hyperthyroidism, cirrhosis, anorexia nervosa, and certain drugs. Long-term calorie restriction of more than 50 percent increases SHBG, while lowering free and total testosterone and estradiol.
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SHBG is made in the liver. Is there something odd there?