New labs are in and it appears that I overshot and underthought the new dosing protocol.
Old protocol 0.5mg T / week two doses. Result: All levels were half of what they thought they should have been. Remedy, double T dose, keep AI the same. I thought everything would be in line.
New protocol 1mg T / week three doses. Result: levels are overhsot by ± 30%.
The huge change in levels (3x original levels) come from the excessive increase in dose, the calculation of which was done without taking into account the difference in the timing of the tests in relation to each other and the concomittant troughs and their levels differing due to the new injection protocol.
I.E. Prior test was done ±3.5 days since last injection. Newest test was performed ± 2.3 days since last injection.
All that changed from last labs to new labs was the doubling of the T dose.
1st figures are prior labs, 2nd new labs.
E2: 43 pmol/L : 132 pmol/L
SHBG: 14.1nmol/L : 15.5 nmol/L
TT: 12nmol/L : 32.4 nmol/L
FT: 355 pmol/L: 1047 pmol/L
So, T dose is doubled but all figures trippled? At least they are in line with each other…This makes me think that my supposition above is correct.
This kind of like explains the E2 symptoms movement between low and high mentioned in my previous post as well as explaining excessive BP readings (High E2 = water retention = increased BP) (Maybe…)
So my recommendation is to reduce T dose to .75ml/w which represents around a 30% reduction in T dose. If all else is linear, I should expect to see E2 reduce to about 93/94 not so? If so, E2 is still to high. By my calculations, by adding 1 drop AI to every dose, I should come in at around 80…
What I am thinking of now of course is that these are trough values, not maximum…is that a problem?
Make these changes, let it rest for another 4 weeks and see where we are. How does that sound?