Just Started TRT, Longterm Side Effects?

Hi guys,

I’m 35 and had scores of 153 and 240 last year (real pathetic). I just started 100 every week. over the past few years my libido was horrible and I was always irritable. When I take it I feel calm. Has anyone been on this long term and not had any side effects?



Side effects come from TRT that is not done properly or not addressing any other problems such as low thyroid function or low cortisol.

At your age, some effort should have been made to find out why your T was low as low-T is a symptom, not the disease.

Most common side effect is from elevated estradiol - E2. Your body aromatizes T–>E2 and an aromatase inhibitor can be used to modulate E2 to an optimal level. Drug of choice is 1mg anastrozole per week in divided doses.

Testes typically can get quite small and scrotum can pull up tight as TRT shuts down LH/FSH. Injected hCG can compensate.

You should self inject T:

  • 50mg twice a week
  • 0.5mg anastrozole at time of injections
  • 250iu hCG SC EOD to preserver the testes and fertility

Use # 29 0.5ml 1/2" insulin syringes to inject T
Same for hCG or #31 0.5ml 5/16"

Read these stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - provide more info
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Please to not disregard any references to iodine, iodized salt and thyroid. Most guys here have some issues.

Post your pre-TRT labs with ranges.
It is important that LH/FSH was tested, too late now.

Long term, TRT reduces heart attacks and strokes VS non-treatment.

The pretest bloods were test levels, CBC, and PSA

I’m due to go for a blood test in 3 months.

Three months is way too long when starting TRT.

TRT with T alone is a rather bleak prospect.

Ask for these labs at 4 weeks:
prolactin - one time only
FSH - should be close to zero, otherwise cancer suspected.

  • do these if oral body temps are low as per thyroid basics sticky
    fT4 [please not T3, T4]

You doctor did not do any diagnostic work and treated the symptom. Sort of normal for most docs. We see low thyroid function issues so often that it might appear that thyroid problems may be causing secondary hypogonadism.

my labs from a year ago were this from a urologist:

testosterone, total

259.9 ng/dL (249.0-836.0)
prolactin, serum

5.5 ng/mL (2.0-21)

luteinizing hormone, serum

3.3 m[iU]/mL

GE use only - for LinkLogic import when terms are not otherwise specified

54.86 pg/mL (30.00-150.00)

albumin, serum

5.2 g/dL (3.5-5.2)