The impact of hormones varies greatly from individual to individual. As men, ours does not fluctuate as much as the women, but think of the effects of the menstrual cycle on women you have known. Some are not affected at all, others greatly impacted.
As a competitive weightlifter in the 70s and 80s, I was around many using AAS, not just weightlifters, but powerlifters and bodybuilders. There was nothing done with estrogen. Yeah, I know some who had gyno and even needed surgery. Everyone retained fluid. Looking back, I believe some of the “roid rage” (which I always thought was BS) may have been due to elevated E2 levels. So, yes, some had trouble with E2, but most did not and I know of guys with E2 levels over 100 doing fine, better than fine actually.
In hindsight, it makes me wonder about all the guys I read about here with E2 problems. But, it is obvious that this type of forum will attract the guy having problems with their TRT program, like so many using small dosing. Some are simply more sensitive to hormone levels.
It applies just as it does to testosterone. More free E2 means more available doing the stuff E2 does.
Mine was 55 when last checked and I have felt much better since dropping anastrozole, as I have mentioned, lipids and joints benefited the most.