Jackolee’s Next Cycle Log

Congratulations of all the hard work and excellent showing. Now that you are going full supra physiological, you may want to look into beefing up your defensive/safety strategy as I mentioned above. Not a lot of human data of course but there is mechanistic justification/theoretical benefit in these ancillaries. FYI:

Taurine ~3 g of bulk powder in water, protective to multiple organs, liver, gonads, heart

Losartan 25-50 mg ED for cardio-protective effects even to non AAS users. Seems like a no brainer as protective measure if going full cycle

https://www.fasebj.org/doi/abs/10.1096/fasebj.24.1_supplement.1040.1

https://insights.ovid.com/crossref?an=00005768-201110000-00004

Lipoic acid, 600-1200 mg/day
Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2/HO-1 pathway, and down-regulation of TNFR1 expression - PubMed

In addition I’d be interested in hearing others experience using oxandrolone troches instead of oral delivery to bypass first-pass metabolism and reduce liver toxicity and lower minimum effective dose. Since oxandrolone has excellent oral bioavailability (97-98%) and is actually metabolized partially by kidneys (haven’t found the studies to support this assertion), I have a hard time believing that sublingual/buccal adminstration is going to do much to limit liver damage. I’ve pulled 10-15 studies and most seem to show similar pharmacokinetics for oral and sublingual administration for drugs that are metabolized similarly (ie CYP 3A4). One way to find out.

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