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Type two is less severe than Type one, but more common. This type occurs when the pancreas can’t make enough insulin and loses its ability to use it. It also occurs when enough insulin is produced but the body cannot use it. It is linked with age, obesity, and a lifestyle lacking exercise."
"Type 2 diabetes is often part of a metabolic syndrome that includes obesity, elevated blood pressure, and high levels of blood lipids. Unfortunately, as more children become overweight, type 2 diabetes is becoming more common in young people.
When type 2 diabetes is diagnosed, the pancreas is usually producing enough insulin, but, for unknown reasons, the body cannot use the insulin effectively, a condition called insulin resistance. "
“Type II diabetes usually occurs gradually. Some 75% to 80% of people with type II diabetes are obese at the time of diagnosis. The disease can also develop in lean people, especially the elderly. Genetics play a large role in type II diabetes and family history is a risk factor. However, environmental factors such as a low activity level and poor diet can increase a person?s risk for type II diabetes. Other risk factors are as follows: obesity; race/ethnicity (African-Americans, Hispanic-Americans, Native Americans, Asian-Americans, Pacific Islanders); age greater than 45 years; previously identified impaired glucose tolerance; hypertension (high blood pressure); HDL cholesterol of less than 35 and/or triglyceride level of greater than 250; history of gestational diabetes mellitus or babies over nine pounds.”
"Type II diabetes is associated with obesity and with aging. It is a lifestyle-dependent disease, and has a strong genetic component (concordance in twins is 80-90%). The problem seems not so much in insulin production,but that when the insulin reaches its target cells, it doesn’t work correctly.Most Type II diabetes patients initially have high insulin levels along with high blood sugar. However, since sugar signals the pancreas to release insulin,Type II diabetics eventually become resistant to that signal and the endocrine-pancreas soon will not make enough insulin. These people end up managing the disease with insulin and they need much higher doses because they are resistant to it.
When a person takes in a high load of sugar, the sugar stimulates the pancreas to release insulin. The targets for insulin are muscle, fat, and liver cells.These cells have insulin receptor sites on the outside of the cell membrane.For most people, when insulin has bound to the receptors, a cascade of events begins, which leads to sugar being transported from the blood into the interior of the cell. In Type II diabetics, even when insulin is present on the cell membrane, the process doesn’t work. The glucose is never taken up into the cell and remains in the bloodstream."