As for the sublingual method, I’ve been using all of my oral steroids this way for quite a while. I can tell the delivery is much more efficient due to the “kick” I recieve that swallowing doesn’t give. I sually prepare the inside of my mouth with alcohol to increase permeability and to help the tablet dissolve.
What kind of alcohol?
So is all of this really scientifically viable? And would this method actually reduce stress on the liver and improve speed of uptake?
Of course it is scientifically viable. Absorption under the tongue is really efficient. As for reducing stress on the liver, it doesn’t go through the liver the first time (aka first pass) so that is a 100% reduction of the first pass effect.
The means by which drugs have to go through the first pass is because they get absorbed on certain points of the enteral tract which goes through the “hepatic portal veins” leading right to the liver. Sublingual administration of any drug avoids that completely.
As for the speed of uptake, it’s really not a big difference, but yes it is faster, since it is going straight from under the tongue into systemic circulation.
I may be wrong, but I believe this method was originally discovered as a solution do the administration of drugs that were not stable in acid (ie basic drugs) since the stomach acid would break them down. It’s actually quite neat.
I’ve read about drugs being taken sublingually, but I guess I figured if it was so effective with respect to oral AAS, that I would have read about it somewhere before now. 100%?
I mean, in theory, this would render oral steroids basically safe to administer in long cycles without worry of liver damage, right? Somehow it just seems to me that if this were true, a helluva lot more people would be doing it this way. I’d love to be proven wrong.
Yes 100%. If it doesn’t go through the hepatic portal veins, it’s not going to the liver before it reaches systemic circulation. It’s not really refutable. It’s a physiological and pharmacological fact. It’s effective with any drug that isn’t contained in a protective capsule (the drug is in that capsule for a reason, whether to protect it or you).
That second statement is incorrect. Yes it would render any liver-hard drug a bit safer, but don’t forget that every drug has to go through the liver a final time before it is excreted, to be metabolized. So, in the end, everything you put in your body goes through your liver. It really is a marvelous and wondrous organ.