No, but could be better.
My PSA was never high, but has decreased over 11 years of TRT. I have always managed E2 in lower 20’s.
E2 is now recognized as a factor with prostate problems.
PSA can be elevated by prostatitis [infections/inflammation]. Also never have PSA labs soon after ejaculation or after a prostate digital exam [DRE] as levels will be elevated.