Basically what VT said. The "in-range" really doesn't hold any validity. I'm pretty sure they have changed what is "in-range" on a regular basis. If you were in the bottom range, and just 1 point above, you'd be considered "fine" although you'd probably have the sex drive of a dead chicken. If you were at the upper limits (also fine) you'd probably have trouble concentrating unless you were locked in a dark room without internet access.
Is Bio-Signature valid? I'm pretty sure even Poliquin himself has said that it is based off "typical" results.
So it is more of a "people who had similair results, had these problems". if you need to squeak out every last bit of potential you have, or that is something you can afford to do with the ungodly amount of supplements that Bio-Sig recommends, then go for it.
If not, for your Test, take some Alpha Male. For your Cortisol, get some more sleep. Insulin resistance, lose some fat. And liver function, read Liver Let Die by John Meadows, and do everything on there.